On Tuesday morning, Jared Isaacman, a billionaire entrepreneur, launched to space for a second time. The missionmwplay888, known as Polaris Dawn, is a collaboration between Mr. Isaacman and SpaceX, the rocket company led by Elon Musk.

“Send us, SpaceX,” Mr. Isaacman said with just over 30 seconds left in the countdown.

At 5:23 a.m. Eastern time, a Falcon 9 rocket lifted off from NASA’s Kennedy Space Center in Florida. Less than 15 minutes later, the crew of four astronauts inside the Crew Dragon capsule — that will be their home for the next five days — were in orbit.

“We’re going to get to work now,” Mr. Isaacman said in an exchange with the launch controllers on the ground.

The Polaris Dawn mission will mark some milestones for private spaceflight — the first spacewalk conducted by nonprofessional astronauts, and the farthest journey from Earth by anyone since NASA’s moon landings more than 50 years ago.

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SKIP ADVERTISEMENTWhy was the flight delayed?

The launch was scheduled for Aug. 28, but was called off because of a helium leak. After that, unsettled weather around Florida has proved troublesome — not so much for the launch, but for the splashdown on the sixth day.

The Polaris Dawn mission carries limited amounts of air, food, and other supplies. “Unlike an I.S.S. mission, we don’t have the option to delay long on orbit, so we must ensure the forecast is as favorable as possible before we launch,” Mr. Isaacman explained on X, referring to the International Space Station.

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